NCT03178396

Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Thomas Jefferson University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The investigators will be studying the effect of melatonin on blood pressure, insulin resistance, and platelets, along with possible reasons for how melatonin cases these effects.

Detailed description

The investigators will be studying the effect of melatonin on blood pressure and insulin resistance, and possible reasons for how melatonin works on blood pressure and IR. Along with blood testing to measure adipokines, insulin resistance (IR), and platelet function (how well your blood clots), 24-hour ambulatory blood pressure monitoring (ABPM) will be used to measure blood pressure, since ABPM is the gold standard (best method) for accurate assessment of blood pressure status and associated cardiovascular risk. Vascular (blood vessel) function, IR, adipokine levels and sleep quality will also be measured. All study endpoints will be measured at baseline and following 6 weeks of daily melatonin 9 mg dosing.

Conditions

• Prehypertension
• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	melatonin	controlled release, 9 mg taken 30 minutes before bedtime x 6 weeks

Timeline

• Start date: 2015-12-07
• Primary completion: 2016-08-09
• Completion: 2016-08-09
• First posted: 2017-06-06
• Last updated: 2017-06-08

Locations

1 site across 1 country: United States