Trials / Completed
CompletedNCT03176654
The Effect of Manipulation of the Cervical Spine on Pain Biomarkers
The Effect of High-Velocity Low-Amplitude Thrust Manipulation of the Cervical Spine on Pain Biomarkers in Females With Non-Specific Mechanical Neck Pain
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 28 (actual)
- Sponsor
- Loma Linda University · Academic / Other
- Sex
- Female
- Age
- 20 Years – 45 Years
- Healthy volunteers
- Accepted
Summary
This study evaluates the effect of high-velocity low-amplitude thrust (HVLAT) manipulation to the cervical spine on neuropeptide expression as determined by the plasma concentration of oxytocin, neurotensin, orexin A and cortisol; and Examine the effect of HVLAT manipulation on pain perception in symptomatic females with non-specific mechanical cervical spine pain
Detailed description
A high-velocity low-amplitude thrust (HVLAT) manipulation or commonly known as a spinal manipulation, is an intervention frequently used by physical therapists and other healthcare practitioners as an alternative treatment to help relieve spinal pain The mechanism by which HVLAT manipulation modulates pain remains undefined, although this does not contradict the clinical effects from HVLAT manipulation. Furthermore, there is evidence that suggests analgesia after HVLAT manipulation. There is a variety of observed and proposed phenomena that can explain the mechanisms for the psychological, mechanical, or neurophysiological responses from a HVLAT manipulation associated with alterations in pain processing or sympathetic and motor systems' excitation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | HVLAT manipulation | HVLAT will be performed 10 minutes after the first blood draw. |
| PROCEDURE | Sham HVLAT manipulation | Sham HVLAT will be performed 10 minutes after the first blood draw. |
Timeline
- Start date
- 2016-08-15
- Primary completion
- 2016-09-20
- Completion
- 2016-09-20
- First posted
- 2017-06-05
- Last updated
- 2019-08-01
- Results posted
- 2019-08-01
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03176654. Inclusion in this directory is not an endorsement.