NCT03176641

Platelet-rich Plasma for Meniscus Repair

Efficacy of Platelet-rich Plasma on Meniscus Repair- a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Pei-Yuan Lee, MD · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the effect of platelet-rich plasma (PRP) on meniscus injury by comparing the imaging and clinical outcomes between patients receiving PRP with meniscus repair surgery and those receiving meniscus repair surgery only.

Detailed description

Damage to meniscal tissue is challenging for orthopedic surgeons because of the absence of healing at the avascular zone. Additionally, the accelerated degeneration of articular cartilage and increased rate of knee osteoarthritis that can occur following a meniscal injury. Platelet-rich plasma (PRP) is a fraction of plasma that contains platelets and multiple growth factors concentrated at high level. Because activated platelets have the potential to release growth factors, PRP has been clinically used to accelerate wound healing and tissue regeneration in orthopedic and oral surgery. Several in vivo and in vitro studies have reported favorable outcomes of PRP on meniscal repair; however, the clinical results varied between studies.This clinical trial will investigate the effect of PRP on on meniscus injury. Eligible patients will be randomly assigned to receive PRP with meniscus repair surgery or to receive meniscus repair surgery only. The postoperative imaging and clinical outcomes will be compared and analyzed.

Conditions

• Platelet-Rich Plasma
• Knee Injuries
• Meniscus Disorder

Interventions

Type	Name	Description
OTHER	platelet-rich plasma	Autologous platelet-rich plasma gel applied during meniscus repair surgery
OTHER	control	Meniscus repair surgery only

Timeline

• Start date: 2016-08-24
• Primary completion: 2018-05-08
• Completion: 2018-11-21
• First posted: 2017-06-05
• Last updated: 2018-12-26

Locations

1 site across 1 country: Taiwan