NCT03175861

Modeling of the Response to Hypofractionated Stereotactic Pulmonary Irradiation

Multiscale Modeling / Simulation of the Response to Pulmonary Stereotactic Hypofractionated Irradiation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: University Hospital, Brest · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Identify 18-Fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) parameters predictive of tumor response and local control

Detailed description

The identification of robust prognostic and predictive markers could allow the individualization of pulmonary stereotactic radiotherapy treatments and the selection of patients at high risk of relapse, who could then benefit from a dose escalation in order to increase the chances of local control . Beyond the pulmonary RTS (Radiotherapy in stereotactic condition), this study will aim to generate one or more models of multi-scale response to hypofractionated irradiation from biomarkers (biological or images) extracted from preclinical or clinical literature data and to allow simulations of Various modified fractionation irradiation schemes, potentially leading to new regimens that reduce side effects and increase therapeutic efficacy.

Conditions

• Oncology

Interventions

Type	Name	Description
OTHER	Stereotactic radiotherapy	The patient will have an initial pre-therapeutic assessment in the 8 weeks before the start of radiotherapy Then, radiation therapy planning with 3 free breathing 4D (4 dimensions) scanners performed over 8 days without injection of iodinated contrast agent. Then the patient will receive his treatment by conventional stereotactic radiotherapy

Timeline

• Start date: 2017-06-14
• Primary completion: 2019-06-01
• Completion: 2020-06-01
• First posted: 2017-06-05
• Last updated: 2018-10-19

Locations

4 sites across 1 country: France