NCT03174665

Chronic Neuropathic Pain After Nerve Repair Hand Surgery

Incidence of Chronic Neuropathic Pain and Sensory Deficits After Nerve Repair Hand Surgery (Correlation With Genotypes and Biomarkers)

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 990 (actual)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This study intends to compare the patients with pain with those who underwent same procedure without developing pain. The patients with pain and without pain will be further analyzed in respect to clinical differences, biomarkers and genetical differences.

Detailed description

Chronic pain is a well-known complication after surgery, but the prevalence of persistent pain after upper extremity surgery or other trauma affecting the radial, ulnar or the medial nerve, or branches of these nerves such as digital nerves is unknown. The reason that some patients develop persistent neuropathic pain after surgery, while others, who have been through the exact same procedure or trauma, are pain free is still unknown. The underlying mechanisms are still largely unknown. This can lead to different responses to treatment. Whenever possible, it is important to identify and address the underlying pain mechanisms in the individual patient in order to design an optimal treatment. The aim of this study was to determine the prevalence and the factors implicated in the development of persistent pain after nerve suture surgery investigating Clinical symptoms, standardized clinical examination for neuropathic pain, 92 biomarkers special developed for neuropathic pain, genetics. Conditioned pain modulation and Cold pressor test is intend to be performed in all the patients. \-

Conditions

• Peripheral Nerve Injuries

Interventions

Type	Name	Description
OTHER	No intervention

Timeline

• Start date: 2016-01-01
• Primary completion: 2019-01-01
• Completion: 2019-01-01
• First posted: 2017-06-02
• Last updated: 2017-10-31