NCT03173053

S. Aureus Decolonization in HPN Patients.

Long-term StaphyloCoccus Aureus decolonizAtion in Patients on Home parenteRal nutRition: a randomIzed multicEnter tRial.

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial focusses on identifying the most effective and safe long-term S. aureus carriage decolonization strategy in home parenteral nutrition patients. Half of the participants will receive a quick and short systemic antibiotic treatment combined with topical treatment, while the other half will receive only topical treatment on a periodic basis.

Detailed description

Patients on home parenteral nutrition (HPN) are exposed to a lifelong risk of developing S. aureus bacteremia (SAB). SAB pose a threat to both catheter and patient survival and may lead to a permanent loss of vascular access. S. aureus carriage eradication has proven successful in prevention of S. aureus infections. S. aureus decolonization is a key strategy to maintain venous access and avoid hospitalization.

Conditions

• Staphylococcus Aureus
• Motility Disorder

Interventions

Type	Name	Description
DRUG	Doxycycline	tablet
DRUG	Trimethoprim	tablet
DRUG	Sulfamethoxazole/trimethoprim	tablet
DRUG	Clindamycin	tablet
DRUG	Clarithromycin	tablet
DRUG	Ciprofloxacin	tablet
DRUG	Fusidic Acid	tablet or ointment
DRUG	Rifampin	tablet
DRUG	Chlorhexidine	Mouthwash or bodywash
DRUG	Mupirocin	Nasal ointment
DRUG	Betadine	Shampoo

Timeline

• Start date: 2018-02-08
• Primary completion: 2021-10-14
• Completion: 2021-10-14
• First posted: 2017-06-01
• Last updated: 2022-05-31

Locations

4 sites across 2 countries: Denmark, Netherlands