Trials / Completed
CompletedNCT03172507
The Role of Stem Cells on Immune Cells in the Development of Cardiovascular Diseases
Phenotypic and Epigenetic "Trained Immunity" Characteristics of Hematopoietic Stem and Progenitor Cells in Patients With Established Atherosclerosis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 27 (actual)
- Sponsor
- Radboud University Medical Center · Academic / Other
- Sex
- Male
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
An observational pilot proof-of-principle study. 15 patients with significant coronary artery disease and 15 matched controls. To investigate whether long-term activation of the innate immune system, named 'trained innate immunity', occurs at the level of the bone marrow progenitor cells in patients with significant coronary artery disease and whether this correlates with the proinflammatory phenotype of monocytes.
Conditions
Timeline
- Start date
- 2017-09-20
- Primary completion
- 2018-08-31
- Completion
- 2018-10-01
- First posted
- 2017-06-01
- Last updated
- 2019-04-01
Locations
2 sites across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT03172507. Inclusion in this directory is not an endorsement.