NCT03171558

Gastric Pull up Versus Free Flap Reconstruction for Laryngo-pharyngeal Defects

Gastric Pull up Versus Free Flaps Reconstruction (Anterolateral Thigh and Radial Forearm Free Flap) for Laryngo-pharyngeal Defects: A Prospective Randomized Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will compare the gastric pull up (GPU) with the free flap \[(specifically, anterolateral thigh (ALT) and radial forearm free flap (RFFF)\] techniques used in the reconstruction of alimentary tracts in patients who require laryngectomy and circumferential pharyngectomy for carcinoma resection. These two interventions will be compared by block randomizing 20 patients based on history of failed chemoradiation to undergo either ALT or RFFF. The primary outcome will be the type and number of postoperative complications. The secondary outcomes will include swallowing function, speech, and quality of life measures along with cancer specific endpoints.

Conditions

• Head and Neck Neoplasms
• Pharyngectomy
• Reconstructive Surgical Procedures

Interventions

Type	Name	Description
PROCEDURE	Gastric Pull Up	Using gastric tissue to reconstruct the esophagus and pharynx after pharyngo-esophagectomy.
PROCEDURE	Free Flap Surgery	Using radial forearm free flap or anterolateral thigh free flap to reconstruct the cervical esophagus and pharynx after pharyngectomy and cervical esophagectomy.

Timeline

• Start date: 2017-03-16
• Primary completion: 2022-03-01
• Completion: 2023-03-01
• First posted: 2017-05-31
• Last updated: 2017-05-31

Locations

1 site across 1 country: Canada