Trials / Completed
CompletedNCT03169543
Neural Mechanisms Underlying the Antidepressant Effects of Sleep Deprivation
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 50 (actual)
- Sponsor
- University of Pennsylvania · Academic / Other
- Sex
- All
- Age
- 21 Years – 50 Years
- Healthy volunteers
- Accepted
Summary
From 40 to 60% of patients with depression experience a rapid and significant improvement of mood with one night of sleep deprivation (SD). The neural mechanisms underlying this effect have not been elucidated. Recent advances in functional neuroimaging have provided new opportunities to investigate state changes in regional brain function, along with a better understanding of the neural networks affected by depression and SD. Here we propose to study a group of N=48 antidepressant-free male and female patients with current depression symptom and N=12 healthy controls with no history of mood disorders before and after SD to provide mechanistic insight into the neural substrates underlying the antidepressant effects of SD. We hypothesize that SD-induced concurrent functional activity and connectivity changes in multiple brain networks related to different depressive symptom dimensions including emotion regulation, attention, arousal, self-referential, and reward processing will underlie the rapid and transient antidepressant effects of SD. Using an ABA design, multimodal brain imaging along with more traditional electroencephalographic (EEG) and neurobehavioral testing data will be acquired at baseline after normal sleep, during one night of total SD, and after one night of recovery sleep using a 5-day in laboratory protocol during which subjects will be continuously monitored by trained staff.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Sleep deprivation | 36-hours total sleep deprivation |
Timeline
- Start date
- 2016-04-01
- Primary completion
- 2020-02-28
- Completion
- 2020-02-28
- First posted
- 2017-05-30
- Last updated
- 2020-03-25
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03169543. Inclusion in this directory is not an endorsement.