NCT03168555

Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: Zealand University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Investigate serial plasma samples of fibroblast growth factor 19 (FGF19) after oral stimulation with chenodeoxycholic acid in the same subjects before and after elective cholecystectomy

Detailed description

Lack of FGF19 and elevated 7-alpha-hydroxy-colestenone (C4) is associated with the bile acid diarrhoea (BAD), a disease with increasing estimated of prevalence. BAD is occasionally triggered by cholecystectomy and FGF19 and C4 is known to be affected by cholecystectomy. The investigators are exploring if FGF19 after oral stimulation can be developed to a universal test for BAD, and need to know how the proposed test is affected by cholecystectomy.

Conditions

• Bile Acid Malabsorption
• Cholelithiasis

Interventions

Type	Name	Description
DRUG	chenodeoxycholic acid	1250 mg CDCA is given with a study meal

Timeline

• Start date: 2017-06-22
• Primary completion: 2019-05-15
• Completion: 2019-05-15
• First posted: 2017-05-30
• Last updated: 2022-05-19
• Results posted: 2022-05-19

Locations

1 site across 1 country: Denmark