Trials / Unknown
UnknownNCT03166943
the Possible Effect of the Antiviral Inhibitors for Treatment of Hepatitis C Virus Infection in Cardiac Function
An Investigative Study on the Possible Effect of the Antiviral Inhibitors (Sofosbuvir and Daclatasvir) for Treatment of Hepatitis C Virus Infection in Cardiac Function
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 130 (estimated)
- Sponsor
- Assiut University · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
It has been known for many years that the heart and the liver are intimately related. There is a mutual interaction between the function of the heart and the liver and a broad spectrum of acute and chronic entities that affect both the heart and the liver. Chronic hepatitis C virus infection affects more than 3% (170 million) of the world's population.
Detailed description
Assessment of systolic function by echocardiography will be done to 100 hepatitis C virus infected patients who receive antiviral treatment (sofosbuvir and daclatasvir) by biplane simpson's method and by speckle tracking. Assessment of diastolic function by echocardiography to 30 hepatitis C virus infected patients who will not receive antiviral treatment, by left atrium volume , mitral inflow pattern , tissue doppler annular early and late diastolic velocities .
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Systolic function by echocardiography | Echocardiography for evaluation of systolic function: * by biplane Simpson's method. * by speckle tracking: |
| PROCEDURE | Diastolic function by echocardiography | Echocardiography for evaluation of diastolic function: * Left atrial Volume * Mitral Inflow Patterns * Pulsed wave Doppler * Mitral inflow patterns include normal, impaired left ventricular relaxation, pseudonormal, and restrictive left ventricular filling patterns. * Tissue Doppler Annular Early and Late Diastolic Velocities * Pulsed wave tissue doppler imaging * Primary measurements include the systolic , early diastolic, and late diastolic velocities. |
Timeline
- Start date
- 2017-05-10
- Primary completion
- 2020-12-01
- Completion
- 2020-12-01
- First posted
- 2017-05-25
- Last updated
- 2020-01-22
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT03166943. Inclusion in this directory is not an endorsement.