Trials / Completed
CompletedNCT03165643
The DNA Methylation of ARHGEF11 in Macrosomia
Epigenetic Alteration of Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) in Cord Blood Samples in Macrosomia Exposed to Intrauterine Hyperglycaemia
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 239 (actual)
- Sponsor
- Peking University First Hospital · Academic / Other
- Sex
- Female
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Background Macrosomia at birth is associated with subsequent susceptibility to obesity, abnormal glucose metabolism, hypertension and dyslipidaemia. Epigenetic reprogramming has been reported to be involved in the development of human diseases caused by suboptimal environmental or nutritional factors. Objective The study was aiming to explore epigenetic mechanism influences on macrosomic infants exposed to intrauterine hyperglycemia. Design The investigators performed a genome-wide analysis of DNA methylation in cord blood from macrosomic infants born to women with gestational diabetes or infants with normal birth weight born to normal glucose-tolerant women in order to identify genes related to foetal growth or early adipose tissue development. The candidate genes were then validated using SEQUENOM MassARRAY after bisulfite conversion.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | OGTT | 75 g glucose tolerance test was provided to all pregnant women during 24-28 weeks. |
Timeline
- Start date
- 2014-03-06
- Primary completion
- 2014-10-18
- Completion
- 2014-10-18
- First posted
- 2017-05-24
- Last updated
- 2017-05-24
Source: ClinicalTrials.gov record NCT03165643. Inclusion in this directory is not an endorsement.