NCT03160677

Blood Pressure Target in Acute Stroke to Reduce hemorrhaGe After Endovascular Therapy

Comparison of Two Strategies for Blood Pressure Control in the Setting of Acute Ischemic Stroke to Reduce Cerebral Hemorrhage After Thrombectomy: Systolic Blood Pressure Target of Less Than 130 mmHg vs Less Than 185 mmHg, for 24 Hours Following Reperfusion, in Patients With Cerebral Infarction Due to Occlusion of the Anterior Circulation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 320 (actual)
• Sponsor: Fondation Ophtalmologique Adolphe de Rothschild · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A randomized, multicenter study comparing two strategies: 1 / standard management of systolic blood pressure according to international recommendations (systolic blood pressure \<185 mm Hg) versus 2 / intensive blood pressure management Systolic with a target \<130 mm Hg.

Detailed description

Patients will be followed for 3 months: * inclusion after reperfusion: clinical evaluation with NIHSS (National Institute of Health Stroke Score) score, measurement of blood pressure. * within 24 hours after reperfusion: blood pressure measurements * at 24 hours: measurement of blood pressure (T0 + 24 h and evaluation of the NIHSS score. * Between 24 and 36 hours :cerebral scan (assessment of hemorrhagic transformations and cerebral infarction volumes). For some centers: Cerebral MRI without injection between H24 and H36 * 72 hours after reperfusion: Cerebral scanner in case of hyperdensity on the initial scanner * 3 months after reperfusion: disability assessment by Rankin score

Conditions

• Acute Stroke
• Blood Pressure
• Cerebral Hemorrhage

Interventions

Type	Name	Description
OTHER	Systolic blood pressure target < 130 mm Hg	Adaptation of antihypertensive treatments to reach the Systolic blood pressure target \< 130 mm Hg
OTHER	Systolic blood pressure target < 185 mm Hg	Adaptation of antihypertensive treatments to reach the Systolic blood pressure target \< 185 mm Hg

Timeline

• Start date: 2017-06-21
• Primary completion: 2019-12-31
• Completion: 2020-01-31
• First posted: 2017-05-19
• Last updated: 2021-08-03

Locations

7 sites across 1 country: France