NCT03160651

Corticosteroids in Alcoholic Hepatitis

Corticosteroids in Severe Alcoholic Hepatitis Patients With Early Spontaneous Improvement

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (estimated)
• Sponsor: Erasme University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Approximately 50% of patients admitted for severe AH will have spontaneous improvement of liver function before initiation of therapy (ie decrease in mDF between hospital admission and initiation of steroids). These patients have a better prognosis than patients without spontaneous improvement of liver function. It has never been demonstrated that corticosteroids improve survival in severe AH patients with spontaneous improvement of liver function. Our hypothesis is that severe AH patients with spontaneous improvement of liver function represent a group who could most benefit from steroids

Conditions

• Alcoholic Hepatitis

Interventions

Type	Name	Description
DRUG	Methylprednisolone or placebo	Patients will receive 28 days of methylprednisolone 32 mg/day

Timeline

• Start date: 2018-02-09
• Primary completion: 2022-06-01
• Completion: 2022-12-01
• First posted: 2017-05-19
• Last updated: 2021-02-26

Locations

1 site across 1 country: Belgium