NCT03160066

The Effects of Lactobacillus Rhamnosus (JB-1) on Stress and Cognition

The Effects of Lactobacillus Rhamnosus (JB-1) on Stress and Cognition in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: University College Cork · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Emerging evidence suggests that microorganisms acting via the Brain-Gut axis may have potential benefits for the management of stress-related conditions. The majority of studies have focused on animal models. Preclinical studies have identified the Lactobacillus Rhamnosus JB-1 strain as a putative psychobiotic with an impact on stress-related behaviours, physiology and cognitive performance. Whether such preclinical effects could be translated to healthy human volunteers remains unknown.

Detailed description

30 healthy male volunteers will be recruited in a randomized single blind placebo controlled cross over trial. Study participation will involve a screening visit followed by a baseline cognitive test battery, EEG and stress visit (socially evaluated cold-pressor test). These measures will be repeated after 4 weeks of daily probiotic and placebo capsules.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Lactobacillus Rhamnosus (JB-1)	Lactobacillus Rhamnosus (JB-1) capsule
DIETARY_SUPPLEMENT	Placebo	Placebo

Timeline

• Start date: 2015-07-01
• Primary completion: 2016-09-01
• Completion: 2016-09-01
• First posted: 2017-05-19
• Last updated: 2017-05-30

Locations

1 site across 1 country: Ireland