NCT03156894

Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Among the complications of heart transplant, primary dysfunction of the graft (PDG) is the most feared with a net impact on early morbidity and mortality. The all-cause mortality rate at the international level is 10% at 30 days and 34% at one year. Mortality at 30 days is secondary in 66% of cases with DPG or multi-organ failure. The treatment of choice for the more severe PDG remains ECMO-type circulatory mechanical assistance or ventricular assistance. According to several studies, this could reduce early mortality. Early placement and short-term (\<30 days) of support appear to improve survival in the first year after transplantation. The haemodynamic parameters revealing this DPG are not clearly described in the literature. hypothesis of this research is that: * DPG risk factors in strasbourg's hospital center are comparable to other European and international centers. * Simple hemodynamic parameters can be used to detect PDG earlier in order to set up assistance more quickly.

Conditions

• Primary Graft Dysfunction

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-03-01
• Completion: 2018-03-01
• First posted: 2017-05-17
• Last updated: 2018-01-09

Locations

1 site across 1 country: France