NCT03154580

Marijuana Cue-Reactivity & Seeking Behavior in Regular Cannabis Users

Marijuana Cue-Reactivity & Seeking Behavior in Regular Cannabis Users: A Pilot Test of Glutamatergic Modulation

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Wayne State University · Academic / Other
• Sex: All
• Age: 21 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the proposed study is to examine the relationship between marijuana reminders, or "cues", craving for marijuana, and marijuana use. The principal investigator is also assessing whether N-acetylcysteine, can reduce marijuana craving or use.

Detailed description

This study involves three screening sessions that could last about 3 hours each. Part of this study will be conducted on an inpatient unit where the participant will live for 4 straight nights. During the inpatient stay participants will participant in experimental sessions where they will be asked to smoke cigarettes containing either marijuana or placebo (a blank). Participants will be asked to take capsules that could contain N-acetylcysteine or placebo (blank). Participants will be asked to complete questionnaires and have vital signs (blood pressure, heart rate) monitored. Participants will be asked to participate in overnight sleep recordings, a polysomnogram (PSG).

Conditions

• Marijuana Abuse

Interventions

Type	Name	Description
DRUG	N-acetyl cysteine	Participants will receive 4 capsules at 11:15am on each experimental session day.

Timeline

• Start date: 2017-05-01
• Primary completion: 2023-06-27
• Completion: 2023-06-27
• First posted: 2017-05-16
• Last updated: 2024-04-23

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study