NCT03154567

Effects of Stress and Drug-cue Exposure (SCM)

Effects of Stress and Drug-cue Exposure on Craving and Marijuana Seeking Behavior in Regular Cannabis Smokers

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Wayne State University · Academic / Other
• Sex: All
• Age: 21 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the proposed study to examine the links among stress, craving for marijuana, and marijuana reminders, or "cues". In this study, an agent called yohimbine will be used to produce stress-like responses. Yohimbine is known to cause stress response in studies of alcohol and other substance use disorders. This study intends to show it can be used to cause stress in marijuana users as well.

Detailed description

Part of this study will be conducted on a residential unit where participants will live for 7 nights over a 2-week period (4 consecutive nights the 1st week and 3 consecutive nights the 2nd week). During that time, participants can't leave the unit unescorted or have visitors. During the inpatient stay participants will participant in experimental sessions where they will be asked to smoke cigarettes containing either marijuana or placebo (a blank). Participants will be asked to take capsules that could contain yohimbine or placebo (blank). Participants will be asked to complete questionnaires and will have their vital signs (blood pressure, heart rate) monitored throughout each session. Participants will be asked to participate in overnight sleep recordings, a polysomnogram (PSG).

Conditions

• Marijuana Abuse

Interventions

Type	Name	Description
DRUG	Yohimbine	Yohimbine (0mg, 20mg, or 40 mg) will be administered at 11:00am on each of the experimental sessions.

Timeline

• Start date: 2017-11-01
• Primary completion: 2023-10-27
• Completion: 2023-10-27
• First posted: 2017-05-16
• Last updated: 2024-04-23

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study