NCT03152929

Paravertebral Block (PVC) Versus Pectoral Nerve Block (PEC)

Paravertebral Block Versus Pectoral Nerve Block for Analgesia Following Mastectomy

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 89 (actual)
• Sponsor: Corewell Health West · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare two standard methods of pain control management used at Spectrum Health for patients undergoing breast surgery. The two methods being compared are the paravertebral block (PVB) and the pectoral nerve block (PEC). Postoperative pain control is essential following any major operative procedure. A variety of methods have been used to ensure adequate pain control, each with its own advantages and risks. Increasingly, attention has focused on regional methods of analgesia, which may allow for reduction in systemic narcotic use and their associated complications. Proposed benefits of regional analgesia and a resultant reduction in narcotic use include decreased risk of cancer progression, decreased length of stay, and decreased risk of ileus.

Detailed description

The purpose of this study is to compare the clinical profiles of two currently acceptable analgesia techniques. The most common regional block used to achieve postoperative analgesia following mastectomy is the paravertebral block, during which local anesthetic is injected into the paravertebral space which contains the thoracic spinal nerves, between the costotransverse ligament and the pleura. At our institution there has been recent interest in an alternative regional block. The pectoral nerve block is performed by injecting anesthetic between the pectoralis major and the pectoralis minor (PECs I) or between the pectoralis minor and the serratus anterior (PEC II). The proposed advantage of the pectoral nerve block for regional anesthesia during breast surgery is equal analgesic efficacy with fewer potential complications.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
DRUG	Paravertebral Block	20-30 mL 0.5% Ropivacaine
DRUG	Pectoral Nerve Block	20-30 mL 0.5% Ropivacaine

Timeline

• Start date: 2017-03-09
• Primary completion: 2019-05-21
• Completion: 2019-05-21
• First posted: 2017-05-15
• Last updated: 2023-06-06
• Results posted: 2023-06-06

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study