NCT03151603

Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 398 (actual)
• Sponsor: University Medical Center Goettingen · Academic / Other
• Sex: Female
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

It is well known that "over-treatment" of straightforward infections should be avoided as far as possible. Evidence-based data on non antibiotic treatment options for common conditions are therefore needed urgently. This randomised-controlled double blind trial examines whether initial herbal treatment with Uva Ursi, and antibiotic treatment only if symptoms persist, reduces antibiotic consumption in uncomplicated urinary tract infections (UTI) without a negative effect on symptom course and rate of recurrent UTIs. In total, 430 patients presenting with typical UTI symptoms will be included by their GPs and receive randomised either herbal treatment with uva ursi (antibiotics only if symptoms persist), or initial antibiotic treatment. Patients record symptom severity and drug intake in a diary and complete a final questionnaire after 28 days.

Conditions

• Urinary Tract Infections

Interventions

Type	Name	Description
DRUG	Arctuvan	application of a herbal drug
DRUG	Fosfomycin	application of an antibiotic drug
DRUG	Placebo to Arctuvan	application of Placebo to Arctuvan
DRUG	Placebo to Fosfomycin	application of Placebo to Fosfomycin

Timeline

• Start date: 2017-05-03
• Primary completion: 2019-05-19
• Completion: 2019-06-20
• First posted: 2017-05-12
• Last updated: 2019-11-27

Locations

47 sites across 1 country: Germany