Trials / Completed
CompletedNCT03151590
Non-Response to Exercise
Non-Response to Exercise - Identification of Factors Contributing to Exercise Non-response.
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (actual)
- Sponsor
- University Hospital Tuebingen · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this prospective intervention study is to find biomarkers and underlying pathomechanisms for non-response of improvement in glucose metabolism to exercise. An additional goal is to identify non-responders at an early stage, where prevention strategies (pharmacologically or by specific training) will be successful.
Detailed description
At baseline and end of study, an intensive metabolic phenotyping including cerebral insulin sensitivity as well as tissue biopsies are performed in overweight untrained healthy participants at high risk for type 2 diabetes. During the study, an individual exercise training at 80% VO2max is performed for 9 weeks. Before and after the training intervention, acute tissue biopsies after a standardized bout of exercise are obtained.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | exercise training |
Timeline
- Start date
- 2017-01-09
- Primary completion
- 2018-12-31
- Completion
- 2018-12-31
- First posted
- 2017-05-12
- Last updated
- 2020-05-08
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT03151590. Inclusion in this directory is not an endorsement.