NCT03151239

Effect of "Nicotinamide Mononucleotide" (NMN) on Cardiometabolic Function

Effect of NMN (Nicotinomide Mononucleotide) Supplementation on Cardiometabolic Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: Female
• Age: 55 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to understand the effect of the dietary supplement "Nicotinamide mononucleotide" on metabolic health in people.

Detailed description

This study is is looking at the effect of the dietary supplement "Nicotinamide mononucleotide" (NMN) on key cardiovascular and metabolic functions, specifically those that are important risk factors for diabetes and cardiovascular disease. Accordingly, the investigators will evaluate the effect of NMN on how well the hormone insulin works to control blood sugar. The investigators will also look at the effects of NMN on blood lipids; body fat and liver fat; and other blood, fat tissue and muscle tissue markers of cardiovascular (heart) and metabolic health. Data from studies conducted in rodents have shown that NMN supplementation has beneficial effects on cardiovascular and metabolic health, but this has not yet been studied in people.

Conditions

• Glucose Metabolism Disorders

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	NMN supplement	Intervention will last at least 8 weeks in the form of two capsules (250 mg total).
OTHER	Placebo	Intervention will last at least 8 weeks in the form of two capsules.

Timeline

• Start date: 2017-07-01
• Primary completion: 2019-05-30
• Completion: 2021-06-30
• First posted: 2017-05-12
• Last updated: 2021-07-14

Locations

1 site across 1 country: United States