Trials / Terminated
TerminatedNCT03148977
Evaluating MMPs in Burns
Evaluating a Point-of-Care, Quantitative Matrix Metalloproteinase Assay as a Predictor of Successful Graft Take in Patients Undergoing Cutaneous Auto Grafting for Acute Burn Injury- A Pilot Study
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 8 (actual)
- Sponsor
- University of Florida · Academic / Other
- Sex
- All
- Age
- 18 Years – 98 Years
- Healthy volunteers
- Not accepted
Summary
The objective of this study is to determine whether our chemical assay can be used to reliably predict graft take or failure in patients undergoing autologous skin grafting for treatment of acute burn injury.
Detailed description
This is an observational pilot study of patients treated at UF Health Shands Burn Center adult service. This is a study to determine the predictive value of quantifying concentrations of specific MMPs. Coupling this with a specialized collection sample collection system and a calibrated fluorimetry allows for the rapid assessment of MMP concentrations. This assay has been validated as a predictor of failed wound healing in a published clinical study involving chronic open wounds.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Graft | Autogenous skin grafting is the only definitive treatment for the full thickness burn injuries, and thus represents the centerpiece of modern burn care. |
Timeline
- Start date
- 2017-06-09
- Primary completion
- 2020-12-08
- Completion
- 2020-12-08
- First posted
- 2017-05-11
- Last updated
- 2021-03-26
Locations
2 sites across 1 country: United States
Source: ClinicalTrials.gov record NCT03148977. Inclusion in this directory is not an endorsement.