NCT03148535

Guidance Model of Standardized Treatment of Antidepressants in Bipolar Disorder

Clinical Psychopharmacology Division Institute of Mental Health, Peking University

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Peking University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The bipolar depression patients of 18-55 years old were recruited. At the time of enrollment, the demographic, symptomatic, neuropsychological, neurobiological and genetic data was collected. After the completion of the baseline assessment and examination, the patients were given lithium carbonate or lithium carbonate combined with SSRI antidepressant treatment. Clinical evaluation was performed at 2 and 8 weeks after treatment, including the therapeutic efficacy and adverse drug reactions, and monitoring of serum lithium concentration. The patients further receive the fMRI scans after treatment for 8 weeks. Through above work, this study aimed to provide some guidance for the use of antidepressants in patients with bipolar depression.

Conditions

• the Use of Antidepressants in Patients With Bipolar Depression

Interventions

Type	Name	Description
DRUG	Lithium Carbonate	bipolar depression recieve lithium Carbonate treatment
DRUG	lithium carbonate combined with SSRI antidepressant treatment	lithium carbonate combined with SSRI antidepressant treatment

Timeline

• Start date: 2017-06-01
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2017-05-11
• Last updated: 2017-05-11

Locations

4 sites across 1 country: China