NCT03145883

Exercise and Asthma in Obese Adults

Effects of Aerobic Exercise on Asthmatic Responses in Obese Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of Arizona · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

This pilot study will use an unmasked, parallel group, randomized design. Thirty adult overweight or obese subjects with mild-moderate persistent asthma will be randomly assigned to one of two groups: 12-weeks of home-based moderate intensity aerobic exercise versus no intervention. The study will include 2 clinic visits and 12 telephone calls. Exercise testing to assess physical fitness levels will occur during visits 1 and 2. Blood sampling for biomarkers, inflammatory markers, and other assessments will be done.

Detailed description

The primary aim of this pilot study is to recruit and retain obese adults with mild-moderate persistent asthma for a study protocol that includes exercise at a moderate intensity level in a home-based setting. The investigators primary hypothesis is that compared to no intervention, 12-weeks of moderate intensity aerobic exercise will attenuate serum levels of adipokines (leptin, adiponectin), and other pro-inflammatory markers. The investigators will also analyze the effect of the intervention on fitness levels, pulmonary function, asthma symptoms, asthma control, and asthma-related quality of life. Given that this is a proof of concept/feasibility study, there is no primary outcome measure. The following measures will be assessed: * Obesity related biomarkers and other markers of inflammatory responses: * Asthma symptoms and asthma control measures: * Lung function * Fitness levels and physical activity levels:

Conditions

• Asthma in Overweight Adults

Interventions

Type	Name	Description
OTHER	Home-Based Aerobic Exercise

Timeline

• Start date: 2015-07-01
• Primary completion: 2017-09-01
• Completion: 2017-09-01
• First posted: 2017-05-09
• Last updated: 2017-10-16

Locations

1 site across 1 country: United States