NCT03141632

Effects of Glucagon Like Peptide 1 (GLP-1) Analogues on Fluid Intake

Effects of GLP-1 Analogues on Fluid Intake in Healthy Volunteers - "The GATE-Study"

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to elucidate whether GLP-1 analogues influence not only appetite but also thirst perception. It is hypothesized that GLP-1 analogues reduce fluid intake in healthy volunteers compared to Placebo.

Detailed description

GLP-1 analogues are well known to stimulate glucose-induced insulin secretion and to reduce energy intake. Recent findings from animal and human studies suggest a role of GLP-1 in regulating water and salt homeostasis. GLP-1 has been shown to reduce fluid intake after an oral salt load or during a meal - pointing to a hypodipsic effect. The aim of this study is to elucidate whether these putative hypodipsic properties of GLP-1 analogues reduce fluid intake in healthy volunteers compared to placebo assessed during an evaluation visit of 8 hours.

Conditions

• Thirst
• Water-Electrolyte Imbalance

Interventions

Type	Name	Description
DRUG	Dulaglutide	Evaluation visit with assessment of fluid intake
OTHER	Placebo	Evaluation visit with assessment of fluid intake

Timeline

• Start date: 2016-10-17
• Primary completion: 2017-05-01
• Completion: 2017-05-12
• First posted: 2017-05-05
• Last updated: 2017-10-25

Locations

1 site across 1 country: Switzerland