NCT03141476

Adequacy of Perioperative Cefuroxime Dosage According to the BMI

Perioperative Cefuroxime in Obese Patients: Dosage According to the BMI

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Universitätsklinikum Hamburg-Eppendorf · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the dosage of perioperative cefuroxime for obese patients. Dosage was increased if the BMI was over 30kg/m\*m and as well over 50kg/m\*m. Drug levels were measured in blood and tissue.

Detailed description

Cefuroxime is an often used antibiotic for surgery antibiotic prophylaxis to avoid surgical wound infection. In this study the dosage of cefuroxime was adjusted to the BMI: less than 30kg/m\*m: 1,5g 31-50kg/m\*m: 3,0g more than 50kg/m\*m: 4,5g Cefuroxime was applicated 30 to 60 minutes before the begin of surgery. Drug Levels in blood and fat tissue were measured at skin cut (30-60 minutes after application of Cefuroxime), 45 minutes after skin cut (75-105 minutes after minutes after application of Cefuroxime) and at the end of surgery (up to 150 minutes after application of Cefuroxime) . The hypothesis of this study is that adequate drug levels are reached in all groups.

Conditions

• Obesity; Drug

Interventions

Type	Name	Description
DRUG	Cefuroxime 1,5g	Patients with BMI of \<30kg/m\*m: 1,5 g Cefuroxime
DRUG	Cefuroxime 3g	Patients with BMI of 30-50kg/m\*m: 3g Cefuroxime
DRUG	Cefuroxime 4,5g	Patients with BMI of \>50kg/m\*m: 4,5 g Cefuroxime

Timeline

• Start date: 2017-03-01
• Primary completion: 2017-11-12
• Completion: 2017-12-12
• First posted: 2017-05-05
• Last updated: 2018-02-20

Locations

1 site across 1 country: Germany