Trials / Completed
CompletedNCT03140826
Amplification and Selection of Antimicrobial Resistance in the Intestine II
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (actual)
- Sponsor
- University Hospital Tuebingen · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Stool samples will be collected from two groups of neutropenic patients in the case that a therapy with either meropenem or piperacillin/tazobactam is needed due to a suspected infection. The intestinal resistome will be determined and quantified using shotgun metagenomics. Based on this, regression models will be used to determine the actual selection pressure caused by these drugs, and both selective forces will be compared. The results will reveal if there is a drug that causes a lower selection pressure compared to the other. The study aims to generate knowledge that is required to design effective antibiotic stewardship programs.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | meropenem | Antibiotics to treat infections. |
Timeline
- Start date
- 2018-01-30
- Primary completion
- 2020-07-31
- Completion
- 2020-07-31
- First posted
- 2017-05-04
- Last updated
- 2020-08-03
Locations
2 sites across 1 country: Germany
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT03140826. Inclusion in this directory is not an endorsement.