Trials / Completed
CompletedNCT03140462
Influence of Genetic Polymorphism of Donor on Tacrolimus Concentration in Liver Transplant
The Influence of ABCB1、CYP3A4、CYP3A5、POR Genetic Polymorphism of Donor on Tacrolimus Blood Concentration in Liver Transplant Patients
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 96 (actual)
- Sponsor
- National Taiwan University Hospital · Academic / Other
- Sex
- All
- Age
- 20 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
To study the influence of donor's ABCB1、CYP3A4、CYP3A5、POR genetic polymorphism on tacrolimus blood concentration in liver transplant recipients.
Detailed description
This study will start with a retrospective data analysis. The investigators will use the electronic databases of National Taiwan University Hospital to identify patients who underwent liver transplantation, received tacrolimus and were still followed up at the outpatient clinic. Inclusion and exclusion criteria will be applied to screen appropriate participants, and find their donors. And analyze the effect of genetic polymorphism (ABCB1、CYP3A4、CYP3A5、POR) of donors, including other factors of recipients, on the dose normalized trough concentration of tacrolimus.
Conditions
Timeline
- Start date
- 2017-05-21
- Primary completion
- 2018-04-12
- Completion
- 2020-12-31
- First posted
- 2017-05-04
- Last updated
- 2021-08-11
Locations
2 sites across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT03140462. Inclusion in this directory is not an endorsement.