NCT03140397

Oral Bioavailability and Bioactivity of Prenylflavonoids From Hops

Examination of the Bioavailability and Bioactivity of the Two Natural Food Ingredients 6-Prenylnaringenin and 8-Prenylnaringenin.

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: University of Hohenheim · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The prenylflavonoids 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN) are secondary plant substances, almost exclusively found in hops (Humulus lupulus). Both compounds have known potential biological properties, but poor bioavailability due to their low oral absorption and retention. Our study followed a single dose (500 mg 6- or 8-PN), placebo controlled, randomized, double-blind, three armed crossover study design with ≥2-week washout periods. Plasma, PBMC and urine samples were collected at intervals up to 24 h after intake. Investigators investigated the safety, pharmacokinetics and impact of oral prenylflavonoids on the function of cells of the immune system.

Conditions

• Safety After Oral Intake
• Pharmacokinetics After Oral Intake
• Immune Cells Activity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo
DIETARY_SUPPLEMENT	6-prenylnaringenin
DIETARY_SUPPLEMENT	8-prenylnaringenin

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-04-01
• Completion: 2017-12-31
• First posted: 2017-05-04
• Last updated: 2018-03-30

Locations

2 sites across 1 country: Germany