NCT03139929

Measurement of MSFP and Stressed Volume With CardioQ+®

Measurement of Mean Systemic Filling Pressure & Stressed Volume With CardioQ+® Oesophageal Doppler Measurement

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 42 (estimated)
• Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To study the reliablity of MSFP and stressed volume to follow volume loading and to predict fload loading responsiveness in patients after elective coronary artery bypass grafting (CABG) surgery.

Detailed description

In this study the oesophageal Doppler monitor (CardioQ+), arterial pulse wave analysis (via the CardioQ+ and Flotrac device) and central venous pressure (CVP) will be used to estimate mean systemic filling pressure (MSFP) with the inspiratory hold method. Furthermore the MSFParm will be determined using a rapid cuff inflator. From MSFP vascular compliance (Csys) and stressed volume (Vs) will be calculated. The accuracy of Vs to follow a 500 increase in volume will be studied. The accuracy of MSFP and Vs to to predict fluid loading responsiveness will be assessed in 42 patients after elective coronary artery bypass grafting (CABG) surgery. The effect of a standardised fluid loading on parameters of intrinsic contractility and afterload will be determined. The effect of fluid loading on inertia, resistance and elastance will be assessed

Conditions

• Cardiac Surgery
• CABG

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	MSFP	MSFPhold and MSFParm

Timeline

• Start date: 2017-05-09
• Primary completion: 2019-05-05
• Completion: 2020-03-01
• First posted: 2017-05-04
• Last updated: 2020-01-13

Locations

1 site across 1 country: Netherlands