NCT03139890

Macronutrients and Postprandial Vascular Function

The Effects of Macronutrients on Postprandial Vascular Function in Overweight and Slightly Obese Men

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Vascular function decreases following the intake of a mixed meal in some, but not all studies. Differences in the relative amounts of dietary fat, carbohydrates and protein present in the mixed-meal challenges may have contributed to these apparently inconsistent results. Well-designed trials - comparing under rigorously standardized conditions - on the effects of macronutrients on postprandial vascular function are missing. The primary objective of the current study is thus to evaluate in overweight and slightly obese men the effects of the three macronutrients (fat, carbohydrates, and protein) on postprandial vascular function, as assessed by brachial artery flow-mediated vasodilation (FMD). Secondary objectives are to examine postprandial effects on other markers reflecting vascular function, plasma markers for low-grade systemic inflammation and endothelial dysfunction, blood pressure, and serum lipid and plasma glucose metabolism.

Conditions

• Dietary Fats
• Carbohydrates
• Proteins
• Macronutrients
• Vascular Function
• Postprandial Metabolism

Interventions

Type	Name	Description
OTHER	High-fat (HF-LC-LP) milkshake	During this experimental day, men will receive a high-fat milkshake
OTHER	High-carbohydrate (LF-HC-LP) milkshake	During this experimental day, men will receive a high-carbohydrate milkshake
OTHER	High-protein (LF-LC-HP) milkshake	During this experimental day, men will receive a high-protein milkshake

Timeline

• Start date: 2017-12-01
• Primary completion: 2018-09-01
• Completion: 2018-09-01
• First posted: 2017-05-04
• Last updated: 2018-09-13

Locations

1 site across 1 country: Netherlands