NCT03137706

Characterization of Mechanical Tissue Properties in Patients With Pancreatic, Liver, or Colon Cancer

Characterization of Mechanical Tissue Properties in Pancreas, Liver and Colon

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 8 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This pilot research trial studies characterization of mechanical tissue properties in patients with pancreatic, liver, or colon cancer. Mechanical properties and stiffness of the cancerous tissue may be correlated with the standard pathology report that describes the stage of the disease.

Detailed description

PRIMARY OBJECTIVES: I. To determine if our optical polarimeter device is able to measure tissue stiffness across several human cancer types ex vivo. SECONDARY OBJECTIVES: I. To describe the inter- and intra-tumor heterogeneity of tissue stiffness. II. To determine if the measurements made by the optical polarimeter device are non-destructive. TERTIARY OBJECTIVES: I. Perform multi-variable cross-correlation statistical analysis to determine relationships between: tissue stiffness characteristics, molecular level signatures, and cellular level properties, and if numbers permit, response to treatment. OUTLINE: Patients undergo fresh tumor tissue collection at the time of surgery. The fresh tumor tissue samples are analyzed for tissue stiffness measurements using an optical polarimeter device and cell viability using an automated cell counter.

Conditions

• Colon Carcinoma
• Liver and Intrahepatic Bile Duct Carcinoma
• Pancreatic Carcinoma

Interventions

Type	Name	Description
PROCEDURE	Biospecimen Collection	Undergo fresh tumor tissue collection
OTHER	Laboratory Biomarker Analysis	Correlative studies
OTHER	Laboratory Procedure	Tissue stiffness and cell viability analysis

Timeline

• Start date: 2016-11-14
• Primary completion: 2020-10-19
• Completion: 2020-10-19
• First posted: 2017-05-03
• Last updated: 2021-04-05

Locations

1 site across 1 country: United States