Trials / Completed
CompletedNCT03135132
The Effect of Mild Weight Loss on Circulating Metabolite Profiles
Metabolomics Identifies Increases in Acylcarnitine Profiles in Plasma of Overweight Subjects in Response to Mild Weight Loss
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 100 (actual)
- Sponsor
- Yonsei University · Academic / Other
- Sex
- All
- Age
- 20 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
To determine whether low calorie diet (LCD)-induced weight reduction caused changes in plasma metabolites and metabolic traits from baseline.
Detailed description
Over a 12-week clinical intervention period, a randomized, controlled study was carried out; overweight subjects consumed a LCD (approximately 300kcal/d deficit, n=47) or a weight-maintenance diet (control, n=50) were included for analyzing plasma samples and metabolites using an ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Control group | Recommend to consume usual diet during 12-week study period |
| BEHAVIORAL | LCD group | Recommended to reduce calorie intake (a 300 kcal/day); educated to take out 1/3 of a bowl of rice from per meal a day for an easier application of 100kcal deficits, thereby reducing a 300kcal/3 meal/day |
Timeline
- Start date
- 2015-06-01
- Primary completion
- 2016-10-01
- Completion
- 2016-10-01
- First posted
- 2017-05-01
- Last updated
- 2017-05-01
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT03135132. Inclusion in this directory is not an endorsement.