NCT03134495

the Impact of Paediatric Use of Proton Pump Inhibitors on the Risk of Community Acquired Infections.

A Cohort Study to Assess the Impact of Paediatric Use of Proton Pump Inhibitors on the Risk of Community Acquired Infections

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 290,286 (actual)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: All
• Age: 11 Years
• Healthy volunteers: Not accepted

Summary

Pharmacological treatment of physiologic Gastro-esophageal Reflux disease (GERD) is excessive in France, as 65%-85% of children below 11 years are being treated, frequently with Proton Pump Inhibitors (PPIs) PPI have been associated, in adults, with an increase of infection rate but data in pediatry are scarce, especially in community medecine. Recently a study conducted in England brought up controversial results suggesting that the use of PPIs can be associated with a reduced risk of community acquired pneumonia. Our study was aimed to assess, on a population-based database, the association between PPI prescription and community infections in children of 11 years or under.

Conditions

• Community Infections

Interventions

Type	Name	Description
OTHER	all children with at least one prescription of PPI	all children with at least one prescription of PPI
OTHER	all children with no prescription of PPI	all children with no prescription of PPI

Timeline

• Start date: 2015-03-01
• Primary completion: 2015-03-01
• Completion: 2017-04-01
• First posted: 2017-05-01
• Last updated: 2017-05-01

Locations

1 site across 1 country: France