NCT03133260

A Project to Improve the Diagnosis and Prognosis of Myocardial Injury Associated to Non Cardiac Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 800 (actual)
• Sponsor: Parc de Salut Mar · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: —

Summary

Major adverse cardiovascular events are the leading cause of perioperative morbimortality in non-cardiac surgery. Perioperative myocardial infarction is usually asymptomatic, with a mortality around 10-12%. Myocardial Injury in Noncardiac Surgery (MINS), is defined as a myocardial injury that provokes a troponin increase due to myocardial ischemia. MINS is a predictor of morbimortality at short term and at long term. The aim of the study is to improve the diagnosis of myocardial injury after non cardiac surgery in high-risk patients, improve its treatment in case of MINS and establish prevention strategies.

Conditions

• Myocardium; Injury

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Troponin	Troponin will be measured before surgery and postoperative at days 1,2 and 3.
DRUG	Acetylsalicylic acid	100mg acetylsalicylic acid will be started in case of MINS if no contraindication, it will be continued after hospital discharge. We will evaluate cardiovascular complications till 1 year after surgery
DRUG	Statin	40mg atorvastatin will be started in case of MINS if no contraindication, it will be continued after hospital discharge. We will evaluate cardiovascular complications till 1 year after surgery

Timeline

• Start date: 2017-05-02
• Primary completion: 2019-04-30
• Completion: 2021-10-15
• First posted: 2017-04-28
• Last updated: 2022-03-22

Locations

1 site across 1 country: Spain