NCT03133156

Exercise Regulation of Human Adipose Tissue

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 93 (actual)
• Sponsor: Joslin Diabetes Center · Academic / Other
• Sex: All
• Age: 25 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether exercise training leads to changes in the white adipose tissue that are beneficial to the body's regulation of sugar and body weight.

Detailed description

The prevalence of obesity and type 2 diabetes in the United States and worldwide has risen dramatically over the last few decades, resulting in an enormous need for new therapies to treat these conditions. The discovery that beiging of subcutaneous white adipose tissue may increase energy expenditure has led to tremendous interest in beige cells as a potential treatment for diabetes and obesity. An established treatment for type 2 diabetes and obesity is endurance exercise training. Exercise training can improve systemic homeostasis, and although adaptations to skeletal muscle play a critical role in these effects, the underlying mechanisms are not fully understood. Moreover, the contributions of other tissues in these beneficial effects of exercise on metabolism have not been intensively investigated. The study team hypothesizes that exercise training results in fundamental changes to white adipose tissue, including beiging, and these adaptations play an important role in the effects of exercise training to improve metabolic homeostasis.

Conditions

• Healthy
• Obese
• Diabetes Mellitus, Type 2

Interventions

Type	Name	Description
OTHER	Exercise Intervention	10-Week Aerobic Exercise Training

Timeline

• Start date: 2017-06-15
• Primary completion: 2024-01-17
• Completion: 2024-06-24
• First posted: 2017-04-28
• Last updated: 2025-08-14
• Results posted: 2025-08-14

Locations

1 site across 1 country: United States