NCT03130374

Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells

Treatment of Laryngotracheal Stenosis Using Autologous Olfactory-mucosa-derived Mesenchymal Stem Cells

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: The Republican Research and Practical Center for Epidemiology and Microbiology · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis

Detailed description

Trial evaluating the safety and efficacy of olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis. Mesenchymal stem cells are obtained from tissue biopsy of olfactory mucosa using explant method. Biomass of autologous mesenchymal stem cells in 10% human albumin solution is injected submucosally around and over the tissue after removal of a granuloma tissue during surgical intervention.

Conditions

• Tracheal Stenosis
• Laryngeal Stenosis
• Mesenchymal Stem Cells

Interventions

Type	Name	Description
BIOLOGICAL	Olfactory mucosa-derived mesenchymal stem cells	Olfactory mucosa-derived mesenchymal stem cells

Timeline

• Start date: 2017-01-03
• Primary completion: 2019-01-04
• Completion: 2019-05-20
• First posted: 2017-04-26
• Last updated: 2019-06-07

Locations

2 sites across 1 country: Belarus