NCT03126266

Re-Irradiation of Progressive or Recurrent DIPG

ReRAD: A Phase II Canadian Pediatric Brain Tumour Consortium Study of Re-Irradiation as Treatment of Progressive or Recurrent Diffuse Intrinsic Pontine Glioma

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: University of Calgary · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This is a single-arm, non-randomized study of re-irradiation of diffuse intrinsic pontine glioma (DIPG)

Detailed description

Study therapy will consist of radiation therapy (RT) given over 17 treatment days (for 30.6 Gy in fractions of 1.8 Gy) or 20 treatment days (for 36 Gy in 1.8 Gy fractions), depending on the time from completion of the first course of RT. Treatment days will generally be weekdays, not including statutory holidays.

Conditions

• Recurrent or Progressive Diffuse Intrinsic Pontine Glioma

Interventions

Type	Name	Description
RADIATION	re-irradiation	if DIPG has progressed or recurred at 180 days or later from completion of primary radiation therapy, a second course of radiation therapy will be given

Timeline

• Start date: 2017-04-15
• Primary completion: 2024-11-20
• Completion: 2024-11-25
• First posted: 2017-04-24
• Last updated: 2024-12-05

Locations

18 sites across 3 countries: Australia, Canada, New Zealand