NCT03121482

High-flow Nasal Cannula Oxygen Therapy With or Without NIV During the Weaning Period

High-flow Nasal Cannula Oxygen Therapy With or Without Non-invasive Ventilation (NIV) During the Weaning Period: a Multicenter Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 650 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prospective multicenter randomized controlled open-label trial comparing 2 strategies of oxygenation during the post-extubation period in ICU patients at high risk of extubation failure. Patients will be randomized and assigned to one of the two groups, with a 1:1 ratio.

Conditions

• Acute Respiratory Failure Requiring Reintubation

Interventions

Type	Name	Description
DEVICE	HFNC	Gas flow of 50 l/min and FiO2 adjusted to obtain SpO2 ≥ 92%
DEVICE	NIV	Pressure-support level to achieve an expired tidal volume between 6 and 8 ml/kg and PEEP level of 5 cm H2O with FiO2 adjusted to obtain SpO2 ≥ 92%

Timeline

• Start date: 2017-04-20
• Primary completion: 2018-04-17
• Completion: 2018-04-17
• First posted: 2017-04-20
• Last updated: 2019-03-13

Locations

1 site across 1 country: France