NCT03121053

Preventing contrAst Induced Nephropathy After TranscathEter Aortic Valve Replacement

Preventing Contrast Induced Nephropathy After Transcatheter Aortic Valve Replacement

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: St. Antonius Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Chronic kidney disease (CKD) and (subsequent) acute kidney injury are frequent in patients undergoing transcatheter aortic valve implantation (TAVI). Moreover, these patients are easily hypervolemic and susceptible for cardiac decompensation. Prevention of contrast induced nephropathy (CIN) has not yet been studied in these patients, and evidence on different strategies is urgently needed. The objective of this study is to evaluate the efficacy of 250ml 1.4% sodium bicarbonate versus hypotone saline (0.65% sodiumchloride) hydration prior to TAVI in patients with CKD to prevent CIN.

Conditions

• Aortic Valve Disease
• Chronic Kidney Disease
• Contrast Induced Nephropathy
• Acute Kidney Injury

Interventions

Type	Name	Description
DRUG	sodium bicarbonate
DRUG	hypotone saline

Timeline

• Start date: 2016-10-01
• Primary completion: 2018-12-01
• Completion: 2019-01-01
• First posted: 2017-04-19
• Last updated: 2017-04-19

Locations

1 site across 1 country: Netherlands