NCT03114514

Efficacy of Platelet-rich Plasma (PRP) in the Treatment of Dark Circles Under the Eyes

Efficacy of Platelet-Rich Plasma (PRP) in the Treatment of Periorbital Hyperpigmentation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Damascus University · Academic / Other
• Sex: All
• Age: 15 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

10 ml of blood from each patient will be drawn. This blood specimen will be centrifuged in a specific way to get 1 ml of platelet rich plasma (PRP). PRP will be injected into the the skin under the eyes. The treatment course consists of three sessions of PRP injections with one-month intervals between the sessions.

Detailed description

Background: Dark circles around the eyes is a common problem pretending with relatively dark eyelids concerns many patients, especially women, because of the inconvenience caused by esthetic and negative impact on the psyche and the patient's quality of life. There are several causing factors (such as sun exposure, smoking, alcohol, sleep deprivation, genetic and structural factors). variety of treatments have been used for this situation , but without clear results. The term 'Platelet-Rich Plasma (PRP)' is a general term used to describe hanging plasma that has been obtained from whole blood with concentration of platelets higher than normal concentration found in the circulating blood. PRP's work mechanism depends on the fact that platelets contain important substances called (growth factors), which have a known role in the process of reform and renewal of tissues. Aim of the research: This study was designed to evaluate the effectiveness of (PRP) injection in the treatment of dark circles under the eyes. This is an uncontrolled open therapeutic trial study which will be performed at the Hospital of Dermatology and Venereology of Damascus University in Damascus, Syria during the period from June 2016 to June 2017. The results will be assessed by standardized digital photography month after each injection and three months after the latest assessment with the assistant of skin colors scale. In addition, the patient's satisfaction with the results and any treatment-related side effects will be recorded.

Conditions

• Periorbital Hyperpigmentation

Interventions

Type	Name	Description
BIOLOGICAL	PRP	PRP will be injected subcutaneously around the eyes at three different time points with one-month interval

Timeline

• Start date: 2016-06-17
• Primary completion: 2017-04-20
• Completion: 2017-05-10
• First posted: 2017-04-14
• Last updated: 2017-05-16

Locations

1 site across 1 country: Syria