NCT03114267

Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 64 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and mortality in young women and autoimmune thyroid diseases are the most common. Viral infections are the main environmental factors suspected of triggering autoimmune diseases. Several viruses are certainly involved, all of which are possibly capable of triggering an autoimmune response. However, the precise identification of the viruses involved remains to be established. It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in perioperative specimens of thyroid tissue. However, this case-control study did not show any difference between the thyroid group and the group other thyroid pathologies It has been recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is present within the thyrocytes itself.

Conditions

• Autoimmune Diseases
• Chronic Lymphocytic Thyroiditis

Interventions

Type	Name	Description
OTHER	Comparison of the prevalences of the parvovirus genome	Comparison of the prevalences of the parvovirus genome between cases and controls and then of other viruses according to the results of parvoviruses and data from the literature

Timeline

• Start date: 2012-01-06
• Primary completion: 2015-01-06
• Completion: 2015-01-06
• First posted: 2017-04-14
• Last updated: 2017-04-14

Locations

1 site across 1 country: France