NCT03114111

Pilot Study for the Use of Photodynamic Therapy in the Treatment of Seborrheic Dermatitis

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is: 1. To determine the efficacy of photodynamic therapy (PDT) in the treatment of seborrheic dermatitis. 2. To determine how PDT alters the skin microbiome in subjects with seborrheic dermatitis before and after treatment. 3. To determine how PDT alters sebum secretion rates in subjects with seborrheic dermatitis before and after treatment. The researchers hypothesize that PDT will be efficacious in the treatment of seborrheic dermatitis.

Detailed description

This pilot project investigates the use of PDT may be useful in the treatment of seborrheic dermatitis based on the following: The Malassezia spp is capable of forming biofilms, 2) PDT has been shown to be effective against Malassezia spp PDT can break up bioflims of both bacterial and fungal origin and benzoyl peroxide, a prooxidant treatment similar to PDT, has been shown to be effective in the treatment of seborrheic dermatitis.

Conditions

• Seborrheic Dermatitis

Interventions

Type	Name	Description
DRUG	aminolevulinic acid (ALA)
DRUG	Placebo

Timeline

• Start date: 2017-01-01
• Primary completion: 2019-12-04
• Completion: 2019-12-04
• First posted: 2017-04-14
• Last updated: 2021-08-11

Locations

1 site across 1 country: United States