NCT03109613

PEEP and V/Q Mismatch in Premature Infants

Selecting PEEP in Ventilated Premature Infants by Reducing Ventilation/Perfusion Mismatch: a Pilot Feasibility Study

• Status: Terminated
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Children's Hospital of Philadelphia · Academic / Other
• Sex: All
• Age: 0 Days – 28 Days
• Healthy volunteers: Not accepted

Summary

Positive end-expiratory pressure (PEEP) is used in premature infants receiving mechanical ventilation to maintain lungs open and facilitate gas exchange. When ventilation/perfusion mismatch is present, areas of the lung that are open for gas exchange do not match up with areas of the lung that are receiving blood for gas exchange. This study measures the feasibility of enrolling and completing study maneuvers in premature infants for a prospective study measuring the responsiveness of V/Q mismatch to changes in the amount (or level) of PEEP.

Conditions

• Respiratory Insufficiency Syndrome of Newborn
• Infant, Premature, Diseases

Interventions

Type	Name	Description
DEVICE	Positive end-expiratory pressure (PEEP)	level changes as per arm description

Timeline

• Start date: 2016-04-11
• Primary completion: 2018-08-08
• Completion: 2018-08-08
• First posted: 2017-04-12
• Last updated: 2020-11-17

Locations

3 sites across 1 country: United States