NCT03108222

Phosphorus Absorption in Healthy Adults and in Patients With Moderate Chronic Kidney Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Purdue University · Academic / Other
• Sex: All
• Age: 30 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Chronic kidney disease (CKD) affects approximately 26 million Americans with many more at risk for disease development. Elevated serum phosphorus (P) and related abnormalities in P homeostasis due to progressive loss of kidney function are primary driving forces behind cardiovascular dysfunction and mortality in CKD patients. Intestinal P absorption is an critical aspect in P homeostasis but has been understudied, particularly in the early stages of CKD progression. This study aims to determine P absorption in patients with moderate CKD compared to healthy adults.

Conditions

• Chronic Kidney Disease Mineral and Bone Disorder

Interventions

Type	Name	Description
OTHER	Phosphorus Absorption Test	Subjects will undergo a radiophosphorus (P-33) absorption test over two days, that will include an oral administration of P-33 on the 1st day of the test, and an IV administration of P-33 on the 2nd day of the test. P-33 activity from serial serum and urine collections will be determined by scintillation counting, and fractional phosphorus absorption calculated by kinetic modeling.

Timeline

• Start date: 2018-04-25
• Primary completion: 2019-08-30
• Completion: 2019-12-01
• First posted: 2017-04-11
• Last updated: 2019-07-10

Locations

1 site across 1 country: United States