NCT03106246

Circulating Extracellular Vesicles Released by Human Islets of Langerhans

Immune Response to Extracellular Vesicles Released by Human Islets of Langerhans

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Beta-cells release extracellular vesicles (EV) and exosomes under normal and pathophysiologic conditions. These EV contain beta-cell specific autoantigens which may trigger the immune response at the initiation of type 1 diabetes. In this study, beta-cell derived EV will be detected and characterized in human blood samples.

Detailed description

Adult subjects will be recruited with: new onset type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM) as well as islet transplant candidates. Blood samples will be collected at defined intervals to determine beta-cell specific EV and determine the utility of this biomarker as a measure of beta-cell stress or injury.

Conditions

• Type1 Diabetes Mellitus
• Type2 Diabetes
• Islet Cell Transplantation

Timeline

• Start date: 2016-12-01
• Primary completion: 2018-12-01
• Completion: 2019-07-01
• First posted: 2017-04-10
• Last updated: 2017-04-10

Locations

1 site across 1 country: Canada