NCT03102502

Impact of Enhanced External Counterpulsation on Vascular Hemodynamics and Status

Study of the Effects of Enhanced External Counterpulsation on Vascular Hemodynamics and Status

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (actual)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The present study aimed to investigated the effect of Enhanced External Counterpulsation (EECP) on vascular hemodynamics and atherosclerosis, and the underlying shear stress related mechanisms

Detailed description

Patients with coronary heart disease will be randomized into two groups: standard medical treatment and standard medical treatment plus EECP intervention. Hemodynamic parameters, vascular status and function will be measured.

Conditions

• Coronary Heart Disease

Interventions

Type	Name	Description
DEVICE	EECP	Enhanced external counterpulsation (EECP) is a technique for assisting the circulation by decreasing the afterload of the left ventricle and augmenting the diastolic pressure externally by applying a negative pressure to the lower extremities during cardiac systole. EECP therapy is done by sequential inflation of 3 sets of cuffs wrapped around the lower extremities during diastole and deflation of the cuffs during systole. EECP enhances the aortic diastolic blood flow and coronary perfusion, leading to increased arterial wall shear stress in a pulsatile manner.
DRUG	Medical therapy	Guideline- driven standard medical treatment including statins,antiplatelet drugs（aspirin or Clopidogrel ）, anti-ischemic drugs （Nitroglycerin）

Timeline

• Start date: 2017-03-10
• Primary completion: 2018-10-10
• Completion: 2019-01-10
• First posted: 2017-04-05
• Last updated: 2020-11-02

Locations

1 site across 1 country: China