NCT03095846

Cold Induced Activation of Brown Adipose Tissue in Winter Swimmers

Cold Induced Activation of Brown Fat in Winter Swimmers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study investigates cold-induced brown fat activation in winter swimmers and not-winter swimmers by skin temperature measures assessed with infra red thermography imaging and skin temperatures. Winter swimmers and not-winter swimmers will participate in an acute cooling intervention and thermoneutral intervention for comparison of energy expenditure and skin temperatures at the supraclavicular area.

Detailed description

The field of human brown adipose tissue (BAT) research is focused on activation of BAT as a means of manipulating energy expenditure and potentially anti-obesity and anti-diabetic properties of the tissue. This is well established in rodent studies and explained as due to the specific brown fat uncoupling protein 1 (UCP1). Despite increasing evidence that indicates a metabolic regulatory role of BAT in humans, BAT activation/recruitment is not fully understood. Cold induced brown fat activity will be measured by skin temperature measures by means of infra-red thermography imaging and skin temperature. 15 healthy male winter swimmers and 8 healthy male non-winter swimmers (controls) will be included in the study.

Conditions

• Adipose Tissue
• Brown Adipose Tissue
• Brown Fat
• Uncoupling Protein 1
• Adipokines
• Proteomics
• Infra-red Thermography
• BAT
• Winter Swimmers
• Type2 Diabetes
• Proteins

Interventions

Type	Name	Description
PROCEDURE	Cooling	Individualized cooling protocol

Timeline

• Start date: 2017-04-02
• Primary completion: 2018-03-01
• Completion: 2018-03-01
• First posted: 2017-03-30
• Last updated: 2018-03-27

Locations

1 site across 1 country: Denmark