NCT03094039

Initiation of Resuscitation While Attached to the Cord With Congenital Diaphragmatic Hernia

Initiation of Resuscitative Care While on Placental Circulation for Infants With Congenital Diaphragmatic Hernia - a Randomized Pilot Trial

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of Alberta · Academic / Other
• Sex: All
• Age: 10 Minutes
• Healthy volunteers: Not accepted

Summary

This study aims to measure the cardio-respiratory physiological consequences of initiating resuscitation during placental transfusion (PT) with an intact umbilical cord in infants with congenital diaphragmatic hernia (CDH). PT, mainly via delayed cord clamping, has been shown to offer a higher circulating blood volume, less need for blood transfusion, less need for inotropes in infants. Currently infants with CDH receive immediate cord clamping (ICC) to facilitate immediate resuscitation including immediate intubation and mechanical ventilation. With the development of a resuscitation platform (iNSPiRE), resuscitative care can now be commenced from birth in infants with CDH to benefit from PT.

Conditions

• Congenital Diaphragmatic Hernia

Interventions

Type	Name	Description
PROCEDURE	Ventilatory support while attached to the cord	Infants will receive active resuscitative care (intubation and ventilation) using a specific designed platform for 120 seconds during delayed cord clamping. Then the cord will be clamped forgoing resuscitation care.
PROCEDURE	Immediate cord clamping	Infants will receive immediate cord clamping, transferred to the resuscitation table, intubated and mechanical ventilated according to our current Congenital Diaphragm Hernia protocol.

Timeline

• Start date: 2017-04-27
• Primary completion: 2019-08-31
• Completion: 2019-08-31
• First posted: 2017-03-29
• Last updated: 2019-10-03

Locations

1 site across 1 country: Canada